Endocrine Abstracts

That obesity protects mammals from osteoporosis led us to show in the past that bone remodeling, and thereby bone mass, is regulated by the adipocyte-derived hormone leptin via a central relay and the sympathetic nervous system. To test whether in response to this regulation bone could exert a feedback control of energy homeostasis we performed a functional genetic screen in mice designed to identify genes expressed specifically in osteoblasts, encoding signaling molecules and...